cees dekker Things To Know Before You Buy

Applying solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our research pursuits contain:

Human Rad51 filaments on double- and single-stranded DNA: correlating typical and irregular sorts with recombination perform.

Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins

Due to the fact 2000, Dekker has shifted the key focus of his do the job in direction of biophysics exactly where he experiments the Homes of single biomolecules and cells utilizing the tools of nanotechnology. This alteration of discipline was pushed by his fascination to the remarkable operating of Organic molecular constructions, as well as by the extended-phrase standpoint that a lot of intriguing discoveries is often envisioned in this area.[5] Recent traces of exploration in his biophysics team are during the areas of:[six]

2015, discovery that condensin is really a very flexible protein structure; and very first detection of DNA knots using nanopores

Illustration (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in grey, the rim with the pore is highlighted in crimson, along with a 3D rendering of your motion of the DNA rod is shown.

We form microorganisms into types that deviate from their all-natural phenotype. Particularly, I'll exhibit our capacity to shape live E. coli microbes into novel styles for example rectangles, squares, triangles and circles.

Dynamic ParB–DNA interactions initiate and preserve a partition condensate for bacterial chromosome segregation

Let's say, instead of making use of common leading-down silicon electronics, transistors may be built from the bottom up employing one organic molecules because the switching aspects? This concept, which turned The idea of currently’s industry of molecular electronics, initial emerged while in the seventies.

Bulk-surface area coupling identifies the mechanistic connection concerning Min-protein designs in vivo and in vitro

[14] In 2005 Dekker became linked to Netherlands-huge conversations about Smart Style, a motion that he has considering the fact that Plainly distanced himself from. Dekker advocates that science and religion usually are not in opposition but may be harmonized.

Cees Dekker is Distinguished College Professor at TU Delft. Skilled to be a physicist, he pioneered nanotechnology with several discoveries on carbon nanotubes from the 1990s. Considering that 2000, he moved to one-molecule biophysics and nanobiology. His recent investigate focuses on (i) nanopores for protein sequencing; (ii) chromosome framework, especially SMC motor protein; and (iii) creating a residing artificial cell from lifeless molecules. Dekker is surely an elected member with the KNAW and fellow towards the APS along with the IOP.

2008, 1st observation of protein-coated DNA translocation via nanopores; settled the origin of the electrophoretic drive on DNA in nanopores; ceesdekker.net uncovered a major velocity improve of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of sound in carbon nanotubes in liquid

2004, discovery of recent physics in translocation of DNA by means of nanopores; first experimental review of ions conduction in nanofluidic channels; 1st electrochemistry with individual one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; very first biophysics characterization of the mechanical Houses of double-stranded RNA; and initial one-molecule research of DNA translocation by a restriction-modification enzyme.